Renin-Angiotensin System: A Review of Historical Perspectives

The article is a review of publications concerning historical perspectives the renin-angiotensin system. discovery its components presented in chronological order, beginning with initial identification renin and proceeding to subsequent discoveries angiotensin-converting enzyme 2, angiotensin- (1-7), Mas receptor.
 This paper presents modern classification system, dividing it into classical non-classical branches, based on determination biological effects components. Significant attention devoted elucidating biochemical cascade physiological transformations, implications human body processes. detrimental cardiac system are highlighted, along crucial role played by alternative axis counteracting development cardiovascular diseases.
 data involvement 2 receptors coronavirus infections, susceptibility infection, disease progression.